Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design
about
Comparative modelling of barley-grain aspartic proteinase: A structural rationale for observed hydrolytic specificityRole of somatic cells on dairy processes and products: a reviewSeveral cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferaseStructure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparumCrystal structure of human pepsin and its complex with pepstatinBACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinIdentification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD)Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime RegionCrystal structure of cardosin A, a glycosylated and Arg-Gly-Asp-containing aspartic proteinase from the flowers of Cynara cardunculus LThe potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiaeCrystal structure of type II peptide deformylase from Staphylococcus aureusConformational switching in an aspartic proteinaseEffects of Glycosylation on the Enzymatic Activity and Mechanisms of ProteasesCathepsin D--many functions of one aspartic proteaseAnalysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymesConformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation EquilibriaChemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsGrassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and DComputation of the physio-chemical properties and data mining of large molecular collections.Penicillopepsin-JT2, a recombinant enzyme from Penicillium janthinellum and the contribution of a hydrogen bond in subsite S3 to k(cat).Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations.Understanding HIV-1 protease autoprocessing for novel therapeutic development.Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors.Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cellsHuman napsin A: expression, immunochemical detection, and tissue localization.Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish.Partial venom gland transcriptome of a Drosophila parasitoid wasp, Leptopilina heterotoma, reveals novel and shared bioactive profiles with stinging Hymenoptera.New cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines.Cathepsin D deficiency is associated with a human neurodegenerative disorder.High resolution crystal structure of human β-glucuronidase reveals structural basis of lysosome targeting.Structural studies of vacuolar plasmepsinsCathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74In silico pharmacology for drug discovery: applications to targets and beyondStructure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.Prime region subsite specificity characterization of human cathepsin D: the dominant role of position 128.Novel method for probing the specificity binding profile of ligands: applications to HIV protease.Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastomaA novel mutagenesis strategy identifies distantly spaced amino acid sequences that are required for the phosphorylation of both the oligosaccharides of procathepsin D by N-acetylglucosamine 1-phosphotransferase.
P2860
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P2860
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Crystal structures of native a ...... omal targeting and drug design
@ast
Crystal structures of native a ...... omal targeting and drug design
@en
Crystal structures of native a ...... omal targeting and drug design
@nl
type
label
Crystal structures of native a ...... omal targeting and drug design
@ast
Crystal structures of native a ...... omal targeting and drug design
@en
Crystal structures of native a ...... omal targeting and drug design
@nl
prefLabel
Crystal structures of native a ...... omal targeting and drug design
@ast
Crystal structures of native a ...... omal targeting and drug design
@en
Crystal structures of native a ...... omal targeting and drug design
@nl
P2093
P2860
P3181
P356
P1476
Crystal structures of native a ...... omal targeting and drug design
@en
P2093
E T Baldwin
J W Erickson
R C Sowder
R E Cachau
P2860
P304
P3181
P356
10.1073/PNAS.90.14.6796
P407
P577
1993-07-15T00:00:00Z