Irreversible binding of zomepirac to plasma protein in vitro and in vivo
about
Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation.Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?Irreversible binding of an anticancer compound (BI-94) to plasma proteins.Drug bioactivation, covalent binding to target proteins and toxicity relevance.Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.Drug-protein conjugation and its immunological consequences.Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology.Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury.Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite.Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites.Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac.Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma.Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans.Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver.Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse.Identification of coenzyme A-related tolmetin metabolites in rats: relationship with reactive drug metabolites.Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat.Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro.The influence of physicochemical properties on the reactivity and stability of acyl glucuronides †.Palladium(II)-catalysed regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from alkenes via anti-Markovnikov selectivity.
P2860
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P2860
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
description
1986 nî lūn-bûn
@nan
1986 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի մարտին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@ast
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@en
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@nl
type
label
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@ast
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@en
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@nl
prefLabel
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@ast
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@en
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@nl
P2093
P2860
P356
P1476
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
@en
P2093
A F McDonagh
P2860
P356
10.1172/JCI112392
P407
P577
1986-03-01T00:00:00Z