Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.
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Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures.Structural Mechanism of Ring-opening Reaction of Glucose by Human Serum AlbuminBiomonitoring Human Albumin Adducts: The Past, the Present, and the FutureDiclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolitesMass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients.Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.Drug bioactivation, covalent binding to target proteins and toxicity relevance.Minimising the potential for metabolic activation in drug discovery.Metabolic activation in drug-induced liver injury.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology.Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac.Methylhexahydrophthalic anhydride adducted albumin tryptic peptides in nasal lavage fluid.Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans.Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver.Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide.Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical specieIrreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro.Stereoselective binding properties of naproxen glucuronide diastereomers to proteins.
P2860
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P2860
Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Evidence for covalent binding ...... d by tandem mass spectrometry.
@ast
Evidence for covalent binding ...... d by tandem mass spectrometry.
@en
type
label
Evidence for covalent binding ...... d by tandem mass spectrometry.
@ast
Evidence for covalent binding ...... d by tandem mass spectrometry.
@en
prefLabel
Evidence for covalent binding ...... d by tandem mass spectrometry.
@ast
Evidence for covalent binding ...... d by tandem mass spectrometry.
@en
P2093
P2860
P356
P1476
Evidence for covalent binding ...... d by tandem mass spectrometry.
@en
P2093
A F McDonagh
A L Burlingame
J C Ojingwa
P2860
P304
P356
10.1073/PNAS.90.9.3797
P407
P577
1993-05-01T00:00:00Z