Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice
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Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assaysHeparin cofactor II inhibits arterial thrombosis after endothelial injuryAnnexin II regulates fibrin homeostasis and neoangiogenesis in vivoProtein C anticoagulant and cytoprotective pathwaysCytoprotective-selective activated protein C therapy for ischaemic strokeEndothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosisLaser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombiProthrombotic phenotype of protein Z deficiencyAcute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency.Generation and phenotypic analysis of protein S-deficient mice.Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities.Complete antithrombin deficiency in mice results in embryonic lethality.Regulation of the protein C anticoagulant and antiinflammatory pathways.Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implicationsDisruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.Special considerations in the evaluation of the hematology and hemostasis of mutant mice.Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis.An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia.A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture modelActivated protein C: biased for translation.The characterization of mice with a targeted combined deficiency of protein c and factor XI.A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice.Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge.Accelerated atherogenesis and neointima formation in heparin cofactor II deficient mice.Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.Antibody SPC-54 provides acute in vivo blockage of the murine protein C system.Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis.Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice.AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors.Plasmodium falciparum picks (on) EPCR.Species-specific anticoagulant and mitogenic activities of murine protein S.Historical perspective and future direction of coagulation research.Targeting activated protein C to treat hemophilia.Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner.
P2860
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P2860
Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@ast
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@en
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@nl
type
label
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@ast
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@en
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@nl
prefLabel
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@ast
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@en
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@nl
P2093
P2860
P356
P1476
Inactivation of the gene for a ...... nsumptive coagulopathy in mice
@en
P2093
F J Castellino
L R Jalbert
P Carmeliet
P2860
P304
P356
10.1172/JCI3011
P407
P577
1998-10-15T00:00:00Z