Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
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Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in miceA targeted point mutation in thrombomodulin generates viable mice with a prethrombotic stateMycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer LesionsEndothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosisLaser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombiExpression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous woundsMolecular cloning and sequence analysis of the 5'-flanking region of the Sprague-Dawley rat thrombomodulin gene.KLF2 and KLF4 control endothelial identity and vascular integrityMice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities.Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.Complete antithrombin deficiency in mice results in embryonic lethality.The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implicationsDisruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition.Carboxypeptidase U at the interface between coagulation and fibrinolysis.An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia.Heparan sulfate: antithrombotic or not?A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis.Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosisTissue factor expression during human and mouse development.Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells.Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism.Exacerbation of oxidative stress-induced cell death and differentiation in induced pluripotent stem cells lacking heme oxygenase-1.A guide to murine coagulation factor structure, function, assays, and genetic alterations.Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity.Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin.Historical perspective and future direction of coagulation research.Recombinant thrombomodulin of different domains for pharmaceutical, biomedical, and cell transplantation applications.Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriage.Antisense oligodeoxynucleotides against thrombomodulin suppress the cell growth of lung adenocarcinoma cell line A549.Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program.Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsis.Protective effects of transgenic human endothelial protein C receptor expression in murine models of transplantation.Mutations in the thrombomodulin gene are rare in patients with severe thrombophilia.Characterization and regulation of the 5'-flanking region of the murine endothelial protein C receptor gene.
P2860
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P2860
Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
description
1995 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1995
@ast
im Januar 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/01/31)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/01/31)
@nl
наукова стаття, опублікована в січні 1995
@uk
name
Absence of the blood-clotting ...... nctional cardiovascular system
@ast
Absence of the blood-clotting ...... nctional cardiovascular system
@en
Absence of the blood-clotting ...... nctional cardiovascular system
@nl
type
label
Absence of the blood-clotting ...... nctional cardiovascular system
@ast
Absence of the blood-clotting ...... nctional cardiovascular system
@en
Absence of the blood-clotting ...... nctional cardiovascular system
@nl
prefLabel
Absence of the blood-clotting ...... nctional cardiovascular system
@ast
Absence of the blood-clotting ...... nctional cardiovascular system
@en
Absence of the blood-clotting ...... nctional cardiovascular system
@nl
P2093
P2860
P356
P1476
Absence of the blood-clotting ...... nctional cardiovascular system
@en
P2093
A. M. Healy
H. B. Rayburn
R. D. Rosenberg
P2860
P304
P356
10.1073/PNAS.92.3.850
P407
P577
1995-01-31T00:00:00Z