Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
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Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardationCDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndromeReduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndromeHDAC2 negatively regulates memory formation and synaptic plasticity.Emerging pharmacotherapies for neurodevelopmental disordersThe odyssey of MeCP2 and parental imprintingRett Syndrome: Crossing the Threshold to Clinical TranslationCharacterizing autism spectrum disorders by key biochemical pathways.MECP2 disorders: from the clinic to mice and backMeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?Astrocytes conspire with neurons during progression of neurological diseaseThe impact of MeCP2 loss- or gain-of-function on synaptic plasticityGenetic modifiers of MeCP2 function in Drosophila.Microglia development and functionMeCP2: the chromatin connection and beyondA brain-derived MeCP2 complex supports a role for MeCP2 in RNA processingEnhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxiaBrain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturationUnexpected cellular players in Rett syndrome pathologyMicroglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expressionWild-type microglia arrest pathology in a mouse model of Rett syndrome.Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue MiceAnnual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.Preclinical research in Rett syndrome: setting the foundation for translational success.Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitorCerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets.High levels of MeCP2 depress MHC class I expression in neuronal cells.MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapyUnconventional transcriptional response to environmental enrichment in a mouse model of Rett syndrome.MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain.The role of MeCP2 in brain development and neurodevelopmental disordersGABAA receptor antagonism ameliorates behavioral and synaptic impairments associated with MeCP2 overexpressionMethyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males.DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.Drosophila as a model for MECP2 gain of function in neurons.MeCP2 mutation results in compartment-specific reductions in dendritic branching and spine density in layer 5 motor cortical neurons of YFP-H mice.A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission
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P2860
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
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2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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name
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@ast
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@en
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@nl
type
label
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@ast
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@en
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@nl
prefLabel
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@ast
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@en
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@nl
P2860
P3181
P356
P1476
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
@en
P2093
Caroline F Beard
Sandra Luikenhuis
P2860
P304
P3181
P356
10.1073/PNAS.0401626101
P407
P577
2004-04-20T00:00:00Z