Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia - Wikidata - awgldk - TriplyDB

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q24594559

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Prediction of graft-versus-host disease in humans by donor gene-expression profiling The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint Megakaryocyte biology and related disorders Structural Analysis of the G-Box Domain of the Microcephaly Protein CPAP Suggests a Role in Centriole Architecture The Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication Factor Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice Real-time PCR mapping of DNaseI-hypersensitive sites using a novel ligation-mediated amplification technique.Primary microcephaly: do all roads lead to Rome?Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia.Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia.Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway Mitotic spindle (DIS)orientation and DISease: cause or consequence?Functional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration.Mechanisms of transcription factor deregulation in lymphoid cell transformation.Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas.How does DNA break during chromosomal translocations?Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites Transcription of tal-1, a putative oncogene playing an important role in childhood T-ALL, can be shown in normal peripheral blood cells by a highly sensitive RT-PCR assay.T-cell acute lymphoblastic leukemia and the associated basic helix-loop-helix gene SCL/tal.Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia.TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

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Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q24594559

description

1991 nî lūn-bûn

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1991 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1991 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1991年の論文

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D P Lombardi

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I R Kirsch

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P D Aplan

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P2860

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif

Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma

The SCL gene is formed from a transcriptionally complex locus

Detection of specific sequences among DNA fragments separated by gel electrophoresis

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer

Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity

Splicing of messenger RNA precursors

Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.

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