An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.
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Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic markerTAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic miceAnalysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpointsRegulation of pT alpha gene expression by a dosage of E2A, HEB, and SCLGradient of E2A activity in B-cell development.Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient miceNo requirement for V(D)J recombination in p53-deficient thymic lymphomaDecoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.Murine models of acute leukemia: important tools in current pediatric leukemia research.Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Chromatin immunoselection defines a TAL-1 target geneEnhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceNotch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphomaRetrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsNotch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas.Leukaemia -- a developmental perspective.Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells.Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets.Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphomaHigh-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells.Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.Genetic interaction between Kit and Scl.The molecular basis of T cell acute lymphoblastic leukemiaIdentification of target genes of the p16INK4A-pRB-E2F pathway.Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.Establishment of reproducible xenotransplantation model of T cell acute lymphoblastic leukemia in NOD/SCID mice.SCL assembles a multifactorial complex that determines glycophorin A expression.Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements.The hematopoietic transcription factor SCL binds the p44 subunit of TFIIH.
P2860
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P2860
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
An scl gene product lacking th ...... lignancies in transgenic mice.
@ast
An scl gene product lacking th ...... lignancies in transgenic mice.
@en
type
label
An scl gene product lacking th ...... lignancies in transgenic mice.
@ast
An scl gene product lacking th ...... lignancies in transgenic mice.
@en
prefLabel
An scl gene product lacking th ...... lignancies in transgenic mice.
@ast
An scl gene product lacking th ...... lignancies in transgenic mice.
@en
P2093
P2860
P356
P1433
P1476
An scl gene product lacking th ...... lignancies in transgenic mice.
@en
P2093
Chervinsky DS
Ellsworth M
McGuire EA
P2860
P304
P356
10.1093/EMBOJ/16.9.2408
P407
P577
1997-05-01T00:00:00Z