Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism - Wikidata - awgldk - TriplyDB

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

http://www.wikidata.org/entity/Q24595310

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FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal The neurology of mTOR The role of mTOR signaling in Alzheimer disease Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.Elucidating the role of DEPTOR in Alzheimer's disease.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice JNK3 perpetuates metabolic stress induced by Aβ peptides.Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight.Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions.Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.APP Causes Hyperexcitability in Fragile X Mice.Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.Autophagy and Its Comprehensive Impact on ALS.What's hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders.Targeting the mTOR signaling network for Alzheimer's disease therapy.The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition.The dark sides of amyloid in Alzheimer's disease pathogenesis.Protein recycling pathways in neurodegenerative diseases.The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease.Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.Modulation of Autophagy as a Therapeutic Target for Alzheimer's Disease.Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells.Amino Acid Catabolism in Alzheimer's Disease Brain: Friend or Foe?Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases.Divergent Metabolic Regulation of Autophagy and mTORC1-Early Events in Alzheimer's Disease?Developing BACE-1 inhibitors for FXS.Assessment of Autophagy in Neurons and Brain Tissue.A central role for TOR signalling in a yeast model for juvenile CLN3 disease

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Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

http://www.wikidata.org/entity/Q24595310

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Journal of Biological Chemistry

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Naturally secreted amyloid-bet ...... ia a PRAS40-mediated mechanism

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Andrea Magrí

http://www.w3.org/2001/XMLSchema#string

Antonella Caccamo

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David X Medina

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Monica A Maldonado

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Salvatore Oddo

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Smita Majumder

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Walter Holbein

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Alzheimer's Disease

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Extension of chronological life span in yeast by decreased TOR pathway signaling

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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10.1074/JBC.M110.180638

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