Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
about
POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory gangliaBrn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiationBrn-3a/POU4F1 interacts with and differentially affects p73-mediated transcriptionA role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiationBrn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiationThe DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activityRIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factorsFunctional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factorThe effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neuronsDach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethalityEssential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglionInteraction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survivalBrn3a and Nurr1 mediate a gene regulatory pathway for habenula developmentCardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expressionNkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrainThe BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosisRedundancy of class III POU proteins in the oligodendrocyte lineageDoublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fateHeyL regulates the number of TrkC neurons in dorsal root gangliaBDNF and NT4 play interchangeable roles in gustatory developmentBrn3a target gene recognition in embryonic sensory neuronsAML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemiaAsymmetry in the epithalamus of vertebratesBrn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expressionDynamic expression of transcription factor Brn3b during mouse cranial nerve developmentComparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons.Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells.Truncated, inactive N-acetylglucosaminyltransferase III (GlcNAc-TIII) induces neurological and other traits absent in mice that lack GlcNAc-TIII.Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11.Heterogeneity of glia in the retina and optic nerve of birds and mammals.Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling.Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression.Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice.Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an Atoh7/Math5 lineage reporterBrn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.
P2860
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P2860
Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
description
1996 nî lūn-bûn
@nan
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Targeted deletion of the mouse ...... ovement, and impaired suckling
@ast
Targeted deletion of the mouse ...... ovement, and impaired suckling
@en
Targeted deletion of the mouse ...... ovement, and impaired suckling
@nl
type
label
Targeted deletion of the mouse ...... ovement, and impaired suckling
@ast
Targeted deletion of the mouse ...... ovement, and impaired suckling
@en
Targeted deletion of the mouse ...... ovement, and impaired suckling
@nl
prefLabel
Targeted deletion of the mouse ...... ovement, and impaired suckling
@ast
Targeted deletion of the mouse ...... ovement, and impaired suckling
@en
Targeted deletion of the mouse ...... ovement, and impaired suckling
@nl
P2093
P2860
P921
P356
P1476
Targeted deletion of the mouse ...... ovement, and impaired suckling
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.21.11950
P407
P577
1996-10-15T00:00:00Z