RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift - Wikidata - awgldk - TriplyDB

RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

http://www.wikidata.org/entity/Q24603669

about

Radical SAM-mediated methylation reactions Radical-mediated enzymatic methylation: a tale of two SAMS Structural Basis for Methyl Transfer by a Radical SAM Enzyme Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases Novel modifications in RNA Radical SAM enzymes in methylation and methylthiolation Unusually large deuterium discrimination during spore photoproduct formation.Profound methyl effects in drug discovery and a call for new C-H methylation reactions.Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Complex biotransformations catalyzed by radical S-adenosylmethionine enzymes.In vitro phosphinate methylation by PhpK from Kitasatospora phosalacinea Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy.Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase Radical SAM-dependent carbon insertion into the nitrogenase M-cluster Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Radical S-adenosylmethionine enzymes.S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?Radical S-adenosylmethionine enzymes: mechanism, control and function.The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.Protein and nucleic acid methylating enzymes: mechanisms and regulation Functional implications of ribosomal RNA methylation in response to environmental stress.Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB.Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.Radical SAM-Mediated Methylation of Ribosomal RNA.A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr.Hydrogen transfer in SAM-mediated enzymatic radical reactions.Mutations in RNA methylating enzymes in disease.A QM/MM study of the catalytic mechanism of SAM methyltransferase RlmN from Escherichia coli.The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis.Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.Asymmetric trapping of zwitterionic intermediates by sulphur ylides in a palladium-catalysed decarboxylation-cycloaddition sequence.Methyltransferase Activity of an Iridium Center with Methylpyridinium as Methylene Source

P2860

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P2860

RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

http://www.wikidata.org/entity/Q24603669

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2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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RNA methylation by radical SAM ...... ene transfer and hydride shift

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PNAS.1017781108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

RNA methylation by radical SAM ...... ene transfer and hydride shift

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P2093

Danica Galonic Fujimori

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Feng Yan

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P2860

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

Revisiting the structures of several antibiotics bound to the bacterial ribosome

Adenosylmethionine-dependent synthesis of the glycyl radical in pyruvate formate-lyase by abstraction of the glycine C-2 pro-S hydrogen atom. Studies of [2H]glycine-substituted enzyme and peptides homologous to the glycine 734 site

The catalytic mechanism and structure of thymidylate synthase

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scholarly article

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4315055

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10.1073/PNAS.1017781108

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50267139

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21368151

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P921

rRNA (adenine-C2-)-methyltransferase activity

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3054002

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