A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox
about
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase.156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phoxNADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTSNADPH oxidases in lung health and diseaseStructural insights into Nox4 and Nox2: motifs involved in function and cellular localizationHematologically important mutations: X-linked chronic granulomatous disease (third update)Activation and assembly of the NADPH oxidase: a structural perspectiveAssembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase.Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox.Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.SH3-dependent assembly of the phagocyte NADPH oxidase.Probing the role of the carboxyl terminus of the gp91phox subunit of neutrophil flavocytochrome b558 using site-directed mutagenesis.Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains.NOX enzymes and pulmonary disease.Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display librariesRegulation of NADPH oxidase activity in phagocytes: relationship between FAD/NADPH binding and oxidase complex assembly.The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous diseaseA domain of p47phox that interacts with human neutrophil flavocytochrome b558.NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease.Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or "all that you did and did not want to know about Nox inhibitory peptides".Towards specific NADPH oxidase inhibition by small synthetic peptides.NADPH oxidases: new actors in thyroid cancer?Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain.Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages.Induction of antimicrobial pathways during early-phase immune response to Salmonella spp. in murine macrophages: gamma interferon (IFN-gamma) and upregulation of IFN-gamma receptor alpha expression are required for NADPH phagocytic oxidase gp91-stimNeutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly.Mutagenesis of an arginine- and lysine-rich domain in the gp91(phox) subunit of the phagocyte NADPH-oxidase flavocytochrome b558.Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease.Interaction of human neutrophil flavocytochrome b with cytosolic proteins: transferred-NOESY NMR studies of a gp91phox C-terminal peptide bound to p47phox.Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study.Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery.Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation.
P2860
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P2860
A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@ast
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@en
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@nl
type
label
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@ast
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@en
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@nl
prefLabel
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@ast
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@en
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@nl
P2093
P2860
P356
P1476
A point mutation in gp91-phox ...... proteins p47-phox and p67-phox
@en
P2093
A J Verhoeven
B G Bolscher
J H Leusen
P M Hilarius
R S Weening
P2860
P304
P356
10.1172/JCI117207
P407
P577
1994-05-01T00:00:00Z