Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization - Wikidata - awgldk - TriplyDB

Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization

Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization

http://www.wikidata.org/entity/Q28267075

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Genetic disorders coupled to ROS deficiency Nox family NADPH oxidases in mechano-transduction: mechanisms and consequences Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system Redox balance dynamically regulates vascular growth and remodeling NADPH oxidases in lung health and disease Identification of NOX2 regions for normal biosynthesis of cytochrome b558 in phagocytes highlighting essential residues for p22phox binding Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4 Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors Role of NADPH oxidases in liver fibrosis.Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells Decoding NADPH oxidase 4 expression in human tumors.Nox4 B-loop creates an interface between the transmembrane and dehydrogenase domains.Redox modulation of thimet oligopeptidase activity by hydrogen peroxide P21-activated kinase in inflammatory and cardiovascular disease.Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein Regulation of NADPH oxidase activity in phagocytes: relationship between FAD/NADPH binding and oxidase complex assembly.Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells Redox signaling in cardiac myocytes.The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4 Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension Role of putative second transmembrane region of Nox2 protein in the structural stability and electron transfer of the phagocytic NADPH oxidase.Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease The NOX toolbox: validating the role of NADPH oxidases in physiology and disease.Nox2 is a mediator of chronic CsA nephrotoxicity.Nox2 is a mediator of ischemia reperfusion injury.Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase.Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.Luminal flow induces NADPH oxidase 4 translocation to the nuclei of thick ascending limbs Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22 (phox) N-Terminus: An Elusive Target.Recruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I.Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling.CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity.Therapeutic effects of proteoliposomes on X-linked chronic granulomatous disease: proof of concept using macrophages differentiated from patient-specific induced pluripotent stem cells.Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5.Hydrogen peroxide: a Jekyll and Hyde signalling molecule.Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme.Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease.

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P2860

Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization

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2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Structural insights into Nox4 ...... tion and cellular localization

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Molecular and Cellular Biology

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Structural insights into Nox4 ...... tion and cellular localization

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Deborah Noack

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Jeffrey S Friedman

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Katharina von Löhneysen

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Malcolm R Wood

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Ulla G Knaus

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P2860

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity

Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox

Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity

Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

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10.1128/MCB.01393-09

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4

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19995913

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