Mammalian Cdh1/Fzr mediates its own degradation - Wikidata - awgldk - TriplyDB

Mammalian Cdh1/Fzr mediates its own degradation

Mammalian Cdh1/Fzr mediates its own degradation

http://www.wikidata.org/entity/Q24610309

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Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast.APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway Spatiotemporal regulation of the anaphase-promoting complex in mitosis A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase The eukaryotic linear motif resource ELM: 10 years and counting Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes.Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle.Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.Regulation of APC/C-Cdh1 and its function in neuronal survival Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells A genetic modifier screen identifies multiple genes that interact with Drosophila Rap/Fzr and suggests novel cellular roles.TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1)SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.Degradation of activated protein kinases by ubiquitination.The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy.Processive ubiquitin chain formation by the anaphase-promoting complex.The emerging role of APC/CCdh1 in development.The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.Control the host cell cycle: viral regulation of the anaphase-promoting complex.Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle.Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation.

P2860

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P2860

Mammalian Cdh1/Fzr mediates its own degradation

http://www.wikidata.org/entity/Q24610309

description

2004 nî lūn-bûn

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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2004年の論文

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2004年論文

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2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

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2004年论文

@wuu

name

Mammalian Cdh1/Fzr mediates its own degradation

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Mammalian Cdh1/Fzr mediates its own degradation

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Mammalian Cdh1/Fzr mediates its own degradation

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type

label

Mammalian Cdh1/Fzr mediates its own degradation

@ast

Mammalian Cdh1/Fzr mediates its own degradation

@en

Mammalian Cdh1/Fzr mediates its own degradation

@nl

prefLabel

Mammalian Cdh1/Fzr mediates its own degradation

@ast

Mammalian Cdh1/Fzr mediates its own degradation

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Mammalian Cdh1/Fzr mediates its own degradation

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SJ.EMBOJ.7600149

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The EMBO Journal

P1476

Mammalian Cdh1/Fzr mediates its own degradation

@en

P2093

Aryeh M Weiss

http://www.w3.org/2001/XMLSchema#string

Hiro M Mahbubani

http://www.w3.org/2001/XMLSchema#string

Mario Lebendiker

http://www.w3.org/2001/XMLSchema#string

Michael Brandeis

http://www.w3.org/2001/XMLSchema#string

Tamar Listovsky

http://www.w3.org/2001/XMLSchema#string

Yana Yudkovsky

http://www.w3.org/2001/XMLSchema#string

Yifat S Oren

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1

MAD2B is an inhibitor of the anaphase-promoting complex

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.

Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

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1619-26

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scholarly article

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10.1038/SJ.EMBOJ.7600149

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7

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23

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2004-04-07T00:00:00Z

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8672556

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15029244

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391060

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