The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
about
Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families.Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch populationFunctional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.Molecular genetics of Alzheimer's disease: an update.Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production.Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches.BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways.Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.
P2860
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P2860
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
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The gene encoding nicastrin, a ...... Dutch population-based sample
@ast
The gene encoding nicastrin, a ...... Dutch population-based sample
@en
The gene encoding nicastrin, a ...... Dutch population-based sample
@nl
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label
The gene encoding nicastrin, a ...... Dutch population-based sample
@ast
The gene encoding nicastrin, a ...... Dutch population-based sample
@en
The gene encoding nicastrin, a ...... Dutch population-based sample
@nl
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The gene encoding nicastrin, a ...... Dutch population-based sample
@ast
The gene encoding nicastrin, a ...... Dutch population-based sample
@en
The gene encoding nicastrin, a ...... Dutch population-based sample
@nl
P2093
P2860
P50
P356
P1476
The gene encoding nicastrin, a ...... Dutch population-based sample
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P2093
Ellen Corsmit
Hiroshi Hasegawa
Krist'l Vennekens
Marc Cruts
Marleen Van den Broeck
P2860
P304
P356
10.1086/340732
P407
P50
P577
2002-06-01T00:00:00Z