Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production.
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Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseCholesterol balance in prion diseases and Alzheimer's diseaseOxidized cholesterol as the driving force behind the development of Alzheimer's diseaseEarly etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative DiseasesAllopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's diseaseLocalization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoIncreasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.Cholesterol-modifying strategies for Alzheimer's disease.Seladin-1 expression is regulated by promoter methylation in adrenal cancerEndoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol traffickingFrontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders.Role of vascular risk factors and vascular dysfunction in Alzheimer's disease.Global cPILOT analysis of the APP/PS-1 mouse liver proteome.Cholesterol metabolism and homeostasis in the brainIsoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogasterIncreasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C.Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.Specific antibody binding to the APP672-699 region shifts APP processing from α- to β-cleavageThe Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's DiseaseCholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tanglesNeuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid.Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in RatsHeme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease.Recent advances in applying mass spectrometry and systems biology to determine brain dynamics.Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer diseaseBlood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging.APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides.Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1.Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease.Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits.APP Function and Lipids: A Bidirectional Link.Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer's disease.
P2860
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P2860
Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@en
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@nl
type
label
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@en
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@nl
prefLabel
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@en
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@nl
P2093
P2860
P1476
Cholesterol retention in Alzhe ...... tivities and Abeta production.
@en
P2093
Aimee Jones
Danica B Stanimirovic
Debbie Callaghan
Douglas G Walker
Huaqi Xiong
John Woulfe
Lih-Fen Lue
Lucia I Sue
Wandong Zhang
P2860
P304
P356
10.1016/J.NBD.2007.10.005
P577
2007-11-04T00:00:00Z