Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism - Wikidata - awgldk - TriplyDB

Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism

Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism

http://www.wikidata.org/entity/Q24613339

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Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders Oncostatic-Cytoprotective Effect of Melatonin and Other Bioactive Molecules: A Common Target in Mitochondrial Respiration Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3)Ghrelin.UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein.Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.Therapeutic Potential of Targeting the Ghrelin Pathway.Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.Voluntary exercise reduces the neurotoxic effects of 6-hydroxydopamine in maternally separated rats Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction.Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion.The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion Insulin resistance impairs nigrostriatal dopamine function Neuroprotective actions of ghrelin and growth hormone secretagogues.Physiological roles revealed by ghrelin and ghrelin receptor deficient mice Hypothalamic POMC neurons promote cannabinoid-induced feeding.Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.Relationships between Brain Structure and Metabolic Changes in Schizophrenia Patients Treated with Olanzapine: A Voxel-Based Morphometric Study.Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease Ghrelin and the central regulation of feeding and energy balance.Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease.Preparation of purified perikaryal and synaptosomal mitochondrial fractions from relatively small hypothalamic brain samples An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice.The effects of Δ9-tetrahydrocannabinol on the dopamine system.UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis.Ghrelin increases vagally mediated gastric activity by central sites of action.From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation.Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor.The gut-brain dopamine axis: a regulatory system for caloric intake.Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons.Delayed gastric emptying in Parkinson's disease.The role of ghrelin in neuroprotection after ischemic brain injury.Mitochondrial ROS signaling in organismal homeostasis.Ghrelin and Neurodegenerative Disorders-a Review.Neuroendocrine abnormalities in Parkinson's disease.

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Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism

http://www.wikidata.org/entity/Q24613339

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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Ghrelin promotes and protects ...... endent mitochondrial mechanism

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Ghrelin promotes and protects ...... endent mitochondrial mechanism

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Ghrelin promotes and protects ...... endent mitochondrial mechanism

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JNEUROSCI.3890-09.2009

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Journal of Neuroscience

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Derek Erion

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Jeffrey Zigman

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John D Elsworth

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Joseph M Savitt

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Matthias Tschoep

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Robert H Roth

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Rudolph Beiler

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Tamas L Horvath

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Xiao-Bing Gao

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P2860

Ghrelin controls hippocampal spine synapse density and memory performance

Mice lacking ghrelin receptors resist the development of diet-induced obesity

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Superoxide activates mitochondrial uncoupling proteins

Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

Parkinson's disease: mechanisms and models

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14057-14065

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scholarly article

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1488606

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10.1523/JNEUROSCI.3890-09.2009

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45

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Zane B. Andrews

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38083471

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