The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
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Insights into the Biology and Therapeutic Applications of Neural Stem CellsIncreasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like BehaviorsProtective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.Ghrelin.Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated miceFluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age.Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment.Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse.(56)Fe Particle Exposure Results in a Long-Lasting Increase in a Cellular Index of Genomic Instability and Transiently Suppresses Adult Hippocampal Neurogenesis in Vivo.P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injuryDiscovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.Adult Hippocampal Neurogenesis, Fear Generalization, and Stress.The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation.The current state of the neurogenic theory of depression and anxietyChronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic MiceNovel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.Antidepressant-like effects of acupuncture involved the ERK signaling pathway in ratsShort-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner.Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Diseaseβ1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.NPAS3 Regulates Transcription and Expression of VGF: Implications for Neurogenesis and Psychiatric Disorders.Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.Neuroregeneration versus neurodegeneration: toward a paradigm shift in Alzheimer's disease drug discovery.P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo.Adult Neurogenesis and Psychiatric Disorders.Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis.Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice.Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis.Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood.From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal NeuronsIndole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1.Gut feelings about depression.MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers.Whole-Body Exposure to 28Si-Radiation Dose-Dependently Disrupts Dentate Gyrus Neurogenesis and Proliferation in the Short Term and New Neuron Survival and Contextual Fear Conditioning in the Long Term.Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis.Anxiety, Depression, and the Microbiome: A Role for Gut Peptides.Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats.Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke.
P2860
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P2860
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@ast
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@en
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@nl
type
label
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@ast
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@en
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@nl
prefLabel
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@ast
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@en
The P7C3 class of neuroprotect ...... sing hippocampal neurogenesis.
@nl
P2093
P2860
P356
P1433
P1476
The P7C3 class of neuroprotect ...... asing hippocampal neurogenesis
@en
P2093
A A Pieper
A K Walker
J M Zigman
J-C Chuang
N S Williams
P Huntington
P2860
P2888
P304
P356
10.1038/MP.2014.34
P407
P577
2014-04-22T00:00:00Z