Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.
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A Review of Experimental and Off-Label Therapies for Clostridium difficile InfectionMicrobiota-Regulated IL-25 Increases Eosinophil Number to Provide Protection during Clostridium difficile Infection.Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria.Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer MembraneDefined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model.Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pyloriRole of interleukin 23 signaling in Clostridium difficile colitisRole of leptin-mediated colonic inflammation in defense against Clostridium difficile colitisIntestinal epithelial restitution after TcdB challenge and recovery from Clostridium difficile infection in mice with alanyl-glutamine treatment.Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice.Action of nitroheterocyclic drugs against Clostridium difficile.Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection.Treatment of Clostridium difficile infection in mice with vancomycin alone is as effective as treatment with vancomycin and metronidazole in combinationClick Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.Novel anti-Helicobacter pylori therapies.Small Molecules That Sabotage Bacterial Virulence.Amixicile, a novel strategy for targeting oral anaerobic pathogens.Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms.
P2860
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P2860
Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.
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2012 nî lūn-bûn
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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2012 թվականի մայիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
Amixicile, a novel inhibitor o ...... ile in a mouse infection model
@nl
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@ast
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@en
type
label
Amixicile, a novel inhibitor o ...... ile in a mouse infection model
@nl
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@ast
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@en
prefLabel
Amixicile, a novel inhibitor o ...... ile in a mouse infection model
@nl
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@ast
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@en
P2093
P2860
P50
P356
P1476
Amixicile, a novel inhibitor o ...... le in a mouse infection model.
@en
P2093
Andrew Kennedy
Edward van Opstal
Mary Riggins
Michelle Warthan
Paul S Hoffman
T Eric Ballard
Timothy L Macdonald
P2860
P304
P356
10.1128/AAC.00360-12
P407
P577
2012-05-14T00:00:00Z