Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.
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Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and GiardiaParasitic diarrheal disease: drug development and targetsDrug Resistance in the Microaerophilic Parasite Giardia lambliaPartial inhibition of aldose reductase by nitazoxanide and its molecular basisNitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosisSynthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria.Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer MembraneAntiprotozoal Nitazoxanide Derivatives: Synthesis, Bioassays and QSAR Study Combined with Docking for Mechanistic Insight.Influenza antivirals currently in late-phase clinical trial.Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pyloriSynthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activityBiological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide.Newer antibacterial drugs for a new century.Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces.Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae.Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni.Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuniChallenges of antibacterial discoveryAction of nitroheterocyclic drugs against Clostridium difficile.Discovery of novel antigiardiasis drug candidates.A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides.A small molecule screening to detect potential therapeutic targets in human podocytes.Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.Antimicrobial resistance and the management of anaerobic infections.Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis.Possible links between stress defense and the tricarboxylic acid (TCA) cycle in Francisella pathogenesis.Identification of PPARγ ligands with One-dimensional Drug Profile Matching.Thiazolides: a new class of drugs for the treatment of chronic hepatitis B and C.Nitazoxanide: In vitro and in vivo drug effects against Trichuris muris and Ancylostoma ceylanicum, alone or in combination.Current treatment options for Dientamoeba fragilis infections.Thiazolides: a new class of antiviral drugs.Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model.Novel Helicobacter pylori therapeutic targets: the unusual suspects.Nitazoxanide: nematicidal mode of action and drug combination studies.New antibiotics for selective treatment of gastrointestinal infection caused by Clostridium difficile.Current and future perspectives on the chemotherapy of the parasitic protozoa Trichomonas vaginalis and Entamoeba histolytica.Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuniEvaluating 5-Nitrothiazoles as Trypanocidal Agents.Understanding drug resistance in human intestinal protozoa.
P2860
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P2860
Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@ast
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@en
type
label
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@ast
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@en
prefLabel
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@ast
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@en
P2093
P2860
P50
P356
P1476
Antiparasitic drug nitazoxanid ...... tes, and Campylobacter jejuni.
@en
P2093
Gary Sisson
Kevin Welch
Paul S Hoffman
W Dean Harman
P2860
P304
P356
10.1128/AAC.01159-06
P407
P577
2006-12-11T00:00:00Z