Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox - Wikidata - awgldk - TriplyDB

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

http://www.wikidata.org/entity/Q24623839

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Smallpox vaccines for biodefense: need and feasibility Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor Side-by-side comparison of gene-based smallpox vaccine with MVA in nonhuman primates Vaccinia virus L1 binds to cell surfaces and blocks virus entry independently of glycosaminoglycans Structural basis for the binding of the neutralizing antibody, 7D11, to the poxvirus L1 protein The Structure of the Poxvirus A33 Protein Reveals a Dimer of Unique C-Type Lectin-Like Domains Potent Neutralization of Vaccinia Virus by Divergent Murine Antibodies Targeting a Common Site of Vulnerability in L1 Protein The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy.A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost.Surviving mousepox infection requires the complement system New classes of orthopoxvirus vaccine candidates by functionally screening a synthetic library for protective antigens.The poxvirus A35 protein is an immunoregulator A novel highly reproducible and lethal nonhuman primate model for orthopox virus infection The immunology of smallpox vaccines.Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery Protective properties of vaccinia virus-based vaccines: skin scarification promotes a nonspecific immune response that protects against orthopoxvirus disease.A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice Genetically stable and fully effective smallpox vaccine strain constructed from highly attenuated vaccinia LC16m8 The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies.Antibody against extracellular vaccinia virus (EV) protects mice through complement and Fc receptors.Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge.The myristate moiety and amino terminus of vaccinia virus l1 constitute a bipartite functional region needed for entry Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses Evaluating the orthopoxvirus type I interferon-binding molecule as a vaccine target in the vaccinia virus intranasal murine challenge model.The inability of vaccinia virus A33R protein to form intermolecular disulfide-bonded homodimers does not affect the production of infectious extracellular virus.Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread.Safety and immunogenicity of modified vaccinia Ankara (ACAM3000): effect of dose and route of administration.Effect of vaccination with modified vaccinia Ankara (ACAM3000) on subsequent challenge with Dryvax.Capturing the natural diversity of the human antibody response against vaccinia virus DNA vaccines for biodefense.LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox Poxvirus antigen staining of immune cells as a biomarker to predict disease outcome in monkeypox and cowpox virus infection in non-human primates Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route.Effect of the deletion of genes encoding proteins of the extracellular virion form of vaccinia virus on vaccine immunogenicity and protective effectiveness in the mouse model.Smallpox vaccines: targets of protective immunity.Development of CMX001 for the Treatment of Poxvirus Infections.Multivalent smallpox DNA vaccine delivered by intradermal electroporation drives protective immunity in nonhuman primates against lethal monkeypox challenge.Vaccine-induced protection against orthopoxvirus infection is mediated through the combined functions of CD4 T cell-dependent antibody and CD8 T cell responses.

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Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

http://www.wikidata.org/entity/Q24623839

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

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Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

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Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

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type

label

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@ast

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@en

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@nl

prefLabel

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@ast

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@en

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@nl

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JVI.78.9.4433-4443.2004

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Journal of Virology

P1476

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

@en

P2093

A L Schmaljohn

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C S Schmaljohn

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E Thompson

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M Ait Ichou

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M Zimmerman

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P B Jahrling

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S E Steffen

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P2860

Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997

DNA vaccination with the Hantaan virus M gene protects Hamsters against three of four HFRS hantaviruses and elicits a high-titer neutralizing antibody response in Rhesus monkeys.

Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses.

Real-time PCR assay to detect smallpox virus.

Mapping and nucleotide sequence of the vaccinia virus gene that encodes a 14-kilodalton fusion protein

Epitope detection in the envelope of intracellular naked orthopox viruses and identification of encoding genes.

Developing new smallpox vaccines.

Antibody neutralization of the extracellular enveloped form of vaccinia virus.

Neutralizing and protective antibodies directed against vaccinia virus envelope antigens.

Analysis of the monkeypox virus genome.

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4433-4443

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10.1128/JVI.78.9.4433-4443.2004

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9

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78

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Catherine L Wilhelmsen

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2004-05-01T00:00:00Z

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15078924

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387704

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