Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro
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Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editingThe neurofibromatosis type I messenger RNA undergoes base-modification RNA editingMetabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factorAn auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editingTranscriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRsInduction of RNA editing at heterologous sites by sequences in apolipoprotein B mRNAC-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzymeLength suppression in histone messenger RNA 3'-end maturation: processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNAIdentification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editaseRNA Editing-Systemic Relevance and Clue to Disease Mechanisms?Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editingInduction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activityApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme componentsSecondary structure for the apolipoprotein B mRNA editing site. Au-binding proteins interact with a stem loopMultiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editingMetabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytesAn AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: binding of Apobec-1 to this motif in the 3' untranslated region of c-myc increases mRNA stability.NMR structure of the apoB mRNA stem-loop and its interaction with the C to U editing APOBEC1 complementary factor.Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing.APOBEC-1-mediated RNA editing.Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminaseFunctional characterization of APOBEC-1 complementation factor phosphorylation sites.Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.Intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1 -/- mice.Distinct roles for sequences upstream of and downstream from Physarum editing sites.RNA biology in a test tube--an overview of in vitro systems/assays.Flow-cytometric visualization of C>U mRNA editing reveals the dynamics of the process in live cells.RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing.APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.A sequence-specific RNA-binding protein complements apobec-1 To edit apolipoprotein B mRNA.Editing of human alpha-galactosidase RNA resulting in a pyrimidine to purine conversion.Partial characterization of the auxiliary factors involved in apolipoprotein B mRNA editing through APOBEC-1 affinity chromatography.Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element.Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.Hippocampal Characteristics and Invariant Sequence Elements Distribution of GLRA2 and GLRA3 C-to-U EditingAnalysis of reptilian APOBEC1 suggests that RNA editing may not be its ancestral function.RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency.Two efficiency elements flanking the editing site of cytidine 6666 in the apolipoprotein B mRNA support mooring-dependent editing.
P2860
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P2860
Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro
description
1992 nî lūn-bûn
@nan
1992 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@ast
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@en
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@nl
type
label
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@ast
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@en
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@nl
prefLabel
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@ast
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@en
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@nl
P2860
P356
P1476
Three distinct RNA sequence el ...... B (apoB) RNA editing in vitro
@en
P2093
J W Backus
P2860
P304
P356
10.1093/NAR/20.22.6007
P407
P50
P577
1992-11-25T00:00:00Z