Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
about
The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRsC-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzymeHypermutation induced by APOBEC-1 overexpression can be eliminatedHIV-1 Vif, APOBEC, and intrinsic immunityInduction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factorTwo proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicingApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme componentsMultiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editingApolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing.APOBEC-1-mediated RNA editing.Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.Intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1 -/- mice.The AID/APOBEC family of nucleic acid mutators.The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme.The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions.Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing.Structural and functional assessment of APOBEC3G macromolecular complexes.Flow-cytometric visualization of C>U mRNA editing reveals the dynamics of the process in live cells.APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAs.Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules.Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.Partial characterization of the auxiliary factors involved in apolipoprotein B mRNA editing through APOBEC-1 affinity chromatography.Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot trafficRegulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting.Gene regulation by mRNA editing.Reconstitution of mRNA editing in yeast using a Gal4-apoB-Gal80 fusion transcript as the selectable marker.Two efficiency elements flanking the editing site of cytidine 6666 in the apolipoprotein B mRNA support mooring-dependent editing.Absence of APOBEC-1 mediated mRNA editing in human carcinomas.
P2860
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P2860
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
@en
type
label
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
@en
prefLabel
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
@en
P2860
P356
P1476
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing
@en
P2093
P2860
P304
P356
10.1074/JBC.271.6.3011
P407
P50
P577
1996-02-01T00:00:00Z