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Stable isotope-resolved metabolomics and applications for drug development

Stable isotope-resolved metabolomics and applications for drug development

http://www.wikidata.org/entity/Q24629149

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Application of metabolomics in drug resistant breast cancer research Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Can NMR solve some significant challenges in metabolomics?Two elephants in the room: new hybrid nuclear magnetic resonance and mass spectrometry approaches for metabolomics Metabolomics enables precision medicine: "A White Paper, Community Perspective"Error Analysis and Propagation in Metabolomics Data Analysis.Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks.Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry.Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches.Regulation of glucose metabolism in hepatocarcinogenesis by microRNAs.Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology.Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS.DT-Web: a web-based application for drug-target interaction and drug combination prediction through domain-tuned network-based inference.Metabolomic signature of brain cancer.Omics Screening for Pharmaceutical Efficacy and Safety in Clinical Practice Applications of NMR spectroscopy to systems biochemistry.LC-MS-based Metabolomics of Xenobiotic-induced Toxicities.Analysis of selected sugars and sugar phosphates in mouse heart tissue by reductive amination and liquid chromatography-electrospray ionization mass spectrometry Oncometabolomics in cancer research.Separation technique for the determination of highly polar metabolites in biological samples.Metabolic evaluations of cancer metabolism by NMR-based stable isotope tracer methodologies.Regulation of mammalian nucleotide metabolism and biosynthesis Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates.Extracellular Microbial Metabolomics: The State of the Art.Applying generalized additive models to unravel dynamic changes in anthocyanin biosynthesis in methyl jasmonate elicited grapevine (Vitis vinifera cv. Gamay) cell cultures.Emerging new strategies for successful metabolite identification in metabolomics.Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences.Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics.Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM).Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism.Probing Cancer Cell Metabolism Using NMR Spectroscopy.Combined Analysis of NMR and MS Spectra (CANMS).Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics.Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).Stable Isotope Resolved Metabolomics Studies in Ex Vivo TIssue Slices.Novel strategy for non-targeted isotope-assisted metabolomics by means of metabolic turnover and multivariate analysis.(13)C Tracer Studies of Metabolism in Mouse Tumor Xenografts.Stable isotope labeled metabolomics improves identification of novel metabolites and pathways.

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Stable isotope-resolved metabolomics and applications for drug development

http://www.wikidata.org/entity/Q24629149

description

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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Stable isotope-resolved metabolomics and applications for drug development

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J.PHARMTHERA.2011.12.007

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Pharmacology & Therapeutics

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Stable isotope-resolved metabolomics and applications for drug development

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Andrew N Lane

http://www.w3.org/2001/XMLSchema#string

Hunter N B Moseley

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Katherine Sellers

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Pawel K Lorkiewicz

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Richard M Higashi

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Teresa W-M Fan

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Computational prediction of human metabolic pathways from the complete human genome

The human serum metabolome

Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis

Targeting aspartate aminotransferase in breast cancer

Identification of small molecule inhibitors of pyruvate kinase M2

Molecular imaging in drug development

HMDB: the Human Metabolome Database

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

KEGG: kyoto encyclopedia of genes and genomes

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

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10.1016/J.PHARMTHERA.2011.12.007

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