Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. - Wikidata - awgldk - TriplyDB

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

http://www.wikidata.org/entity/Q33897308

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Clinical significance of T cell metabolic reprogramming in cancer Fundamentals of cancer metabolism Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance MYC, Metabolism, and Cancer Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy Redox control of glutamine utilization in cancer Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Tumour biomarkers: homeostasis as a novel prognostic indicator Caveolin-1 in the regulation of cell metabolism: a cancer perspective Adipose tissue dysfunction and its effects on tumor metabolism Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway.Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis Endothelial cell metabolism: parallels and divergences with cancer cell metabolism Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells OVCAR-3 spheroid-derived cells display distinct metabolic profiles Nutrition and metabolic correlates of obesity and inflammation: clinical considerations.Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA Differentially expressed and activated proteins associated with non small cell lung cancer tissues Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.Melanoma brain metastasis is independent of lactate dehydrogenase A expression Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death Prognostic relevance of lactate dehydrogenase in advanced pancreatic ductal adenocarcinoma patients.Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.Heme oxygenase-1 in macrophages controls prostate cancer progression Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122.Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma.Applications of NMR spectroscopy to systems biochemistry.Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program.Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis A new prognostic score based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer

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P2860

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

http://www.wikidata.org/entity/Q33897308

description

2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.

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Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.

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Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.

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Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.

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Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.

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J.CMET.2014.03.003

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Cell Metabolism

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Targeting lactate dehydrogenas ...... impacts tumor-initiating cells

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P2093

Aaron Grant

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Andrew N Lane

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Han Xie

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Jian-Guo Ren

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Julia Billiard

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Jun-Ichi Hanai

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Kerri Burgess

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Michael Bousamra

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Pankaj Seth

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Parul Bhargava

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P2860

Stable isotope-resolved metabolomics and applications for drug development

The epithelial-mesenchymal transition generates cells with properties of stem cells

Prospective identification of tumorigenic breast cancer cells

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

On the Origin of Cancer Cells

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795-809

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scholarly article

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10.1016/J.CMET.2014.03.003

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5

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19

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Pier Paolo Pandolfi

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