Two species of human CRK cDNA encode proteins with distinct biological activities
about
Activation of Rac1 by a Crk SH3-binding protein, DOCK180Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein CrkRegulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsThe product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent mannerInteraction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptorA novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent mannerInteraction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesisInsulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activationHic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinasec-Abl kinase regulates the protein binding activity of c-CrkCRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cellsExpression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathwaysc-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding proteinDOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membraneIdentification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3GWiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domainsMicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemiaThe adaptor protein Crk in immune responseStructural basis for the transforming activity of human cancer-related signaling adaptor protein CRKDomain organization differences explain Bcr-Abl's preference for CrkL over CrkIIThe integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk couplingDifferential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with CrklInterleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsAssociation of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cellsInterplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transductionPhosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptorInteraction between the amino-terminal SH3 domain of CRK and its natural target proteinsp130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogeneInteractions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factorB cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteinsThe SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15RC-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEFPhosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesisNerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cellsCrkII signals from epidermal growth factor receptor to RasAdapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species
P2860
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P2860
Two species of human CRK cDNA encode proteins with distinct biological activities
description
1992 nî lūn-bûn
@nan
1992 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Two species of human CRK cDNA encode proteins with distinct biological activities
@ast
Two species of human CRK cDNA encode proteins with distinct biological activities
@en
Two species of human CRK cDNA encode proteins with distinct biological activities
@nl
type
label
Two species of human CRK cDNA encode proteins with distinct biological activities
@ast
Two species of human CRK cDNA encode proteins with distinct biological activities
@en
Two species of human CRK cDNA encode proteins with distinct biological activities
@nl
prefLabel
Two species of human CRK cDNA encode proteins with distinct biological activities
@ast
Two species of human CRK cDNA encode proteins with distinct biological activities
@en
Two species of human CRK cDNA encode proteins with distinct biological activities
@nl
P2093
P2860
P3181
P356
P1476
Two species of human CRK cDNA encode proteins with distinct biological activities
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.12.8.3482
P407
P577
1992-08-01T00:00:00Z