Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains - Wikidata - awgldk - TriplyDB

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

http://www.wikidata.org/entity/Q24651136

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Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP Interaction of SPIN90 with syndapin is implicated in clathrin-mediated endocytic pathway in fibroblasts Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin Identification of Nck family genes, chromosomal localization, expression, and signaling specificity WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration A WASp-VASP complex regulates actin polymerization at the plasma membrane.Actin-based motility of intracellular microbial pathogens Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42 Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells The Wiskott-Aldrich syndrome The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion Grb4/Nckbeta acts as a nuclear repressor of v-Abl-induced transcription from c-jun/c-fos promoter elements WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck

P2860

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P2860

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

http://www.wikidata.org/entity/Q24651136

description

1995 nî lūn-bûn

@nan

1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1995 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

1995年の論文

@ja

1995年論文

@yue

1995年論文

@zh-hant

1995年論文

@zh-hk

1995年論文

@zh-mo

1995年論文

@zh-tw

1995年论文

@wuu

name

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@ast

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@en

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@nl

type

label

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@ast

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@en

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@nl

prefLabel

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@ast

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@en

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@nl

P1433

Q24651136-D51AC99E-E606-4D25-89D7-37828535530D

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Q24651136-E7B9B6F5-D92A-4E85-8202-2789670A3674

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Q24651136-3FC43284-13FB-4DE8-B593-8DA846E0D771

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Q24651136-F9961844-C161-43BC-8381-DE1E160FF8BE

P2860

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Q24651136-0B680241-0F83-4A7D-9245-7C64E52E09E7

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Q24651136-2829681F-ABC8-4DA0-BCB3-E9A9E712D9C7

Q24651136-2EBABCBA-91BB-42C1-BDC8-DE8D16AECBEA

Q24651136-2FB6F85E-520D-4F2C-A6B4-E9BE47C47D69

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Q24651136-08145909-5180-4D1C-A82C-30B8208846E6

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Q24651136-EFBBB27D-049D-4906-8B3A-6F39A80D4108

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P1433

Molecular and Cellular Biology

P1476

Wiskott-Aldrich syndrome prote ...... through Src homology 3 domains

@en

P2093

A Marcilla

http://www.w3.org/2001/XMLSchema#string

J H Sameshima

http://www.w3.org/2001/XMLSchema#string

K C Robbins

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions

c-Abl kinase regulates the protein binding activity of c-Crk

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

P304

5725-5731

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scholarly article

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4098726

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P356

10.1128/MCB.15.10.5725

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P407

P433

10

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P478

15

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P50

Octavio Miguel Rivero-Lezcano

P577

1995-10-01T00:00:00Z

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P5875

15632842

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P698

7565724

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P921

Wiskott-Aldrich syndrome

P932

230823

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