Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells
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The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsTransphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregationTyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linkingAggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTPSLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cellsThe protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptorAggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31)Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responsesInteraction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RIStructure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation.Regulation of the adapter molecule Grb2 by the Fc epsilon R1 in the mast cell line RBL2H3.Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors.Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptorsSyk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.Polymerization of actin in RBL-2H3 cells can be triggered through either the IgE receptor or the adenosine receptor but different signaling pathways are used.Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitroDynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cellsFunctional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells.Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells.Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cellsFc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cellsTransmembrane signaling by the high-affinity IgE receptor on membrane preparations.Receptor signaling in immune cell development and function.Distinct effects on M2-type pyruvate kinase are involved in the dimethylsulfoxide-induced modulation of cellular proliferation and degranulation of mast cells.Activation of phospholipase C gamma in Schizosaccharomyces pombe by coexpression of receptor or nonreceptor tyrosine kinases.Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domainsRoles for Ca2+ stores release and two Ca2+ influx pathways in the Fc epsilon R1-activated Ca2+ responses of RBL-2H3 mast cells.Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.Role of alterations in Ca(2+)-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons.Fc receptor-mediated signal transduction.Protein kinase C activator PMA reduces the Ca(2+) response to antigen stimulation of adherent RBL-2H3 mucosal mast cells by inhibiting depletion of intracellular Ca(2+) stores.Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling.Subcloning the RBL-2H3 mucosal mast cell line reduces Ca2+ response heterogeneity at the single-cell level.N-acetyl-L-cysteine inhibits antigen-mediated Syk, but not Lyn tyrosine kinase activation in mast cells.Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE.Temporal regulation of the IgE-dependent 1,2-diacylglycerol production by tyrosine kinase activation in a rat (RBL 2H3) mast-cell line.
P2860
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P2860
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells
description
1992 nî lūn-bûn
@nan
1992 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@ast
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@en
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@nl
type
label
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@ast
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@en
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@nl
prefLabel
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@ast
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@en
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@nl
P2093
P2860
P356
P1476
Fc epsilon R1-mediated tyrosin ...... rat basophilic leukemia cells
@en
P2093
P2860
P304
P356
10.1128/MCB.12.7.3176
P407
P577
1992-07-01T00:00:00Z