Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.
about
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic responseHistone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosisTumor cells express FcgammaRI which contributes to tumor cell growth and a metastatic phenotypeInsulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cellsQualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilizationActivation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphateA role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophagesExclusion of lipid rafts and decreased mobility of CD94/NKG2A receptors at the inhibitory NK cell synapse.Small, mobile FcepsilonRI receptor aggregates are signaling competent.Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.Time-resolved three-dimensional molecular tracking in live cellsContinual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.Adapters in the organization of mast cell signaling.Reaction diffusion modeling of calcium dynamics with realistic ER geometryRegulation of macropinocytosis by p21-activated kinase-1Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.SERS nanosensors that report pH of endocytic compartments during FcεRI transitNtGNL1a ARF-GEF acts in endocytosis in tobacco cells.Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor.Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18)Regulation of the mast cell response to the type 1 Fc epsilon receptor.Src family kinases and lipid mediators in control of allergic inflammation.Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cellsCalcium-dependent clustering of inositol 1,4,5-trisphosphate receptorsNew insights on mast cell activation via the high affinity receptor for IgEFcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.Translation inhibition reveals interaction of 2'-deoxy and 2'-O-methyl molecular beacons with mRNA targets in living cells.c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling.Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation.The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase.The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.Molecular aspects of the endocytic pathway.p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production.Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences.Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.Differential role for mitogen-activated protein kinases in IgE-dependent signaling in human peripheral blood basophils: in contrast to p38 MAPK, c-Jun N-terminal kinase is poorly expressed and does not appear to control mediator release.
P2860
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P2860
Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@ast
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@en
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@nl
type
label
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@ast
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@en
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@nl
prefLabel
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@ast
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@en
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@nl
P2093
P2860
P356
P1476
Wortmannin blocks lipid and pr ...... y Fc epsilon R1 cross-linking.
@en
P2093
A M Martinez
B S Wilson
J M Oliver
J R Pfeiffer
K K Caldwell
S A Barker
P2860
P304
P356
10.1091/MBC.6.9.1145
P577
1995-09-01T00:00:00Z