Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
about
Oxytocin and cardioprotection in diabetes and obesityControl of metabolic and cardiovascular function by the leptin-brain melanocortin pathwayBrain regulation of energy balance and body weight.Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt functionGIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behaviorDevelopmental specification of metabolic circuitryControl of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatmentRole of developmental factors in hypothalamic functionNeural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocinInducible neuronal inactivation of Sim1 in adult mice causes hyperphagic obesity.The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist.Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagiaAblation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.Oxytocin and boneMC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleusNeuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors.Genetic approaches to understanding human obesity.Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus.Melanocortin control of energy balance: evidence from rodent models.Structural Chromosome Abnormalities Associated with Obesity: Report of Four New subjects and Review of Literature.Sim1 inhibits bone formation by enhancing the sympathetic tone in male mice.The "love hormone" oxytocin regulates the loss and gain of the fat-bone relationshipExogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.Feed your head: neurodevelopmental control of feeding and metabolismPeripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats.Replication and extension of association between common genetic variants in SIM1 and human adiposity.Coming full circle: contributions of central and peripheral oxytocin actions to energy balanceIncomplete penetrance and phenotypic variability of 6q16 deletions including SIM1.Oxytocin, feeding, and satiety.Lipopolysacharide Rapidly and Completely Suppresses AgRP Neuron-Mediated Food Intake in Male MiceRare variants in single-minded 1 (SIM1) are associated with severe obesity.Identification of mutations through dominant screening for obesity using C57BL/6 substrainsA New Horizon: Oxytocin as a Novel Therapeutic Option for Obesity and DiabetesLoss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics.Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.The neuropathology of obesity: insights from human disease.
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P2860
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
description
2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@ast
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@en
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@nl
type
label
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@ast
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@en
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@nl
prefLabel
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@ast
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@en
Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@nl
P2093
P2860
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Postnatal Sim1 deficiency caus ...... d Mc4r and oxytocin expression
@en
P2093
Bassil M Kublaoui
Joel K Elmquist
Laurent Gautron
Terry Gemelli
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P304
P3181
P356
10.1523/JNEUROSCI.5444-09.2010
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P577
2010-03-10T00:00:00Z