Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging - Wikidata - awgldk - TriplyDB

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

http://www.wikidata.org/entity/Q24643933

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Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses The good and the bad of being connected: the integrons of aging Lessons from C. elegans: signaling pathways for longevity Aging as an event of proteostasis collapse Changes in Regenerative Capacity through Lifespan Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes DNAJs: more than substrate delivery to HSPA Proteostasis and longevity: when does aging really begin?The P5 disulfide switch: taming the aging unfolded protein response Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease Complex-I-ty in aging Protein homeostasis as a therapeutic target for diseases of protein conformation Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis Regulation of cellular protein quality control networks in a multicellular organism The regulation of the autophagic network and its implications for human disease Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans Fusion of protein aggregates facilitates asymmetric damage segregation The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response Identification of a tissue-selective heat shock response regulatory network Widespread protein aggregation as an inherent part of aging in C. elegans Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways Novel polyglutamine model uncouples proteotoxicity from aging A genetic screening strategy identifies novel regulators of the proteostasis network The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.Epigenetic inheritance of proteostasis and ageing The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease Regulation of cell-non-autonomous proteostasis in metazoans Five Questions (with their Answers) on ER-Associated Degradation Mitochondrial protein quality control: the mechanisms guarding mitochondrial health Transcriptional and epigenetic regulation of autophagy in aging The cell biology of aging A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

P2860

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P2860

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

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2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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Collapse of proteostasis repre ...... n Caenorhabditis elegans aging

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Collapse of proteostasis repre ...... n Caenorhabditis elegans aging

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Anat Ben-Zvi

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Elizabeth A Miller

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Richard I Morimoto

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P2860

Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Age-related changes of nuclear architecture in Caenorhabditis elegans

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

Molecular chaperones as HSF1-specific transcriptional repressors

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

High-throughput in vivo analysis of gene expression in Caenorhabditis elegans

Signal integration in the endoplasmic reticulum unfolded protein response

Autophagy fights disease through cellular self-digestion

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

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35

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106

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19706382

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Caenorhabditis elegans

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2736453

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