PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats - Wikidata - awgldk - TriplyDB

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats

http://www.wikidata.org/entity/Q24644631

about

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model Regulating anxiety with extrasynaptic inhibition.Negative modulation of α₅ GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected].Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.The GABA(A) receptor as a target for photochromic molecules.Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline.A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.Benzodiazepine receptor ligands: a patent review (2006-2012).α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth.The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.A two step synthesis of BzR/GABAergic active flavones via a Wacker-related oxidation.PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats.Neurobiological correlates of state-dependent context fear.GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia.

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P2860

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats

http://www.wikidata.org/entity/Q24644631

description

2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008 թվականի մայիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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J.BRAINRES.2008.02.020

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PWZ-029, a compound with moder ...... ve, avoidance learning in rats

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Ivana Gavrilović

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James M Cook

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Janko Samardzić

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Miroslav M Savić

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Roman Furtmüller

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Sigismund Huck

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Snezana Savić

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Terry Clayton

http://www.w3.org/2001/XMLSchema#string

Werner Sieghart

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P2860

Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures

Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans

Separate mechanisms for short- and long-term memory.

Subunit composition, distribution and function of GABA(A) receptor subtypes.

Anxiogenic-like activity of L-655,708, a selective ligand for the benzodiazepine site of GABA(A) receptors which contain the alpha-5 subunit, in the elevated plus-maze test.

Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks.

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.

The amygdala modulates the consolidation of memories of emotionally arousing experiences.

The effects of a benzodiazepine receptor antagonist beta-carboline ZK-93426 on scopolamine-induced impairment on attention, memory and psychomotor skills.

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150-9

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10.1016/J.BRAINRES.2008.02.020

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1208

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5457294

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