Structure of complement fragment C3b-factor H and implications for host protection by complement regulators - Wikidata - awgldk - TriplyDB

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

http://www.wikidata.org/entity/Q24646723

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Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae Structures of C3b in complex with factors B and D give insight into complement convertase formation Structural basis for engagement by complement factor H of C3b on a self surface Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement Structural basis for complement factor I control and its disease-associated sequence polymorphisms Analysis of binding sites on complement factor I that are required for its activity The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module Overview of C3 Glomerulopathy Inflammogenesis of Secondary Spinal Cord Injury Putting the structure into complement Genetic variants in the complement system predisposing to age-related macular degeneration: a review Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens Structures of the rat complement regulator CrrY Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family Dimerization of complement factor H-related proteins modulates complement activation in vivo Structure of Factor H-binding Protein B (FhbB) of the Periopathogen,Treponema denticola Structural Basis for Complement Evasion by Lyme Disease Pathogen Borrelia burgdorferi Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4 Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)Production of biologically active complement factor H in therapeutically useful quantities Near-planar solution structures of mannose-binding lectin oligomers provide insight on activation of lectin pathway of complement Complement: a key system for immune surveillance and homeostasis Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes.Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations.Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding.Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.A novel quantitative hemolytic assay coupled with restriction fragment length polymorphisms analysis enabled early diagnosis of atypical hemolytic uremic syndrome and identified unique predisposing mutations in Japan.

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P2860

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

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2009 nî lūn-bûn

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2009年の論文

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Nature Immunology

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Structure of complement fragme ...... ction by complement regulators

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Bert J C Janssen

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Jin Wu

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Piet Gros

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You-Qiang Wu

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P2860

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)

Structural basis for complement factor H linked age-related macular degeneration

Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure.

Complement regulation at the molecular level: The structure of decay-accelerating factor

The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Coot: model-building tools for molecular graphics

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10.1038/NI.1755

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7

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10

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John D. Lambris

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26273022

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19503104

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2713992

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