Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity
about
Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirusProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingSimian virus 40 large T antigen: the puzzle, the pieces, and the emerging pictureNuclear protein phosphorylation and growth control.Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis.Dissociation of retinoblastoma gene protein hyperphosphorylation and commitment to enter S phase.Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigenControl of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I.Involvement of simian virus 40 (SV40) small t antigen in trans activation of SV40 early and late promotersSimian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.Protein phosphatase 2A is required for the initiation of chromosomal DNA replication.The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites.Two regions of simian virus 40 T antigen determine cooperativity of double-hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding.Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin.Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen.T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.The replication functions of polyomavirus large tumor antigen are regulated by phosphorylation.Altered phosphorylation of free and bound forms of monkey p53 and simian virus 40 large T antigen during lytic infection.Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
P2860
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P2860
Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity
description
1991 nî lūn-bûn
@nan
1991 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@ast
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@en
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@nl
type
label
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@ast
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@en
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@nl
prefLabel
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@ast
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@en
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@nl
P2093
P2860
P1433
P1476
Protein phosphatase 2A dephosp ...... lation of DNA-binding activity
@en
P2093
D M Virshup
K H Scheidtmann
P2860
P304
P407
P577
1991-04-01T00:00:00Z