cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen
about
Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated In vitro by the phosphorylation state of the polypeptideThe replication protein A binding site in simian virus 40 (SV40) T antigen and its role in the initial steps of SV40 DNA replication.Interaction of the transcription factor TFIID with simian virus 40 (SV40) large T antigen interferes with replication of SV40 DNA in vitro.Replicative functions of minute virus of mice NS1 protein are regulated in vitro by phosphorylation through protein kinase C.The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0.Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylatedStability and function of JC virus large T antigen and T' proteins are altered by mutation of their phosphorylated threonine 125 residues.Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replicationModel for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis.The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.Interactions required for binding of simian virus 40 T antigen to the viral origin and molecular modeling of initial assembly events.The differential requirement for cyclin-dependent kinase activities distinguishes two functions of herpes simplex virus type 1 ICP0.Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function.Role of the hydrophilic channels of simian virus 40 T-antigen helicase in DNA replicationThe simian virus 40 core origin contains two separate sequence modules that support T-antigen double-hexamer assembly.Two regions of simian virus 40 T antigen determine cooperativity of double-hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding.Hypoxia blocks in vivo initiation of simian virus 40 replication at a stage preceding origin unwinding.Assembly of T-antigen double hexamers on the simian virus 40 core origin requires only a subset of the available binding sites.Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin.Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins.Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNACyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunitDifferent oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.
P2860
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P2860
cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@ast
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@en
type
label
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@ast
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@en
prefLabel
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@ast
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@en
P2093
P2860
P1433
P1476
cdc2 phosphorylation of threon ...... s of simian virus 40 T antigen
@en
P2093
A G Wildeman
D R Marshak
P Tegtmeyer
P2860
P304
P407
P577
1993-09-01T00:00:00Z