MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity - Wikidata - awgldk - TriplyDB

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

http://www.wikidata.org/entity/Q24648493

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Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint Shugoshin is a Mad1/Cdc20-like interactor of Mad2 Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss Identification of a MAD2-binding protein, CMT2, and its role in mitosis.Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation A new view of the spindle checkpoint Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 Mad2 transiently associates with an APC/p55Cdc complex during mitosis Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.Regulation of APC activity by phosphorylation and regulatory factors Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase Mad2 overexpression promotes aneuploidy and tumorigenesis in mice The spindle checkpoint requires cyclin-dependent kinase activity Structure of the mitotic checkpoint complex Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2 The APC11 RING-H2 finger mediates E2-dependent ubiquitination.MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function Genetic instability in budding and fission yeast-sources and mechanisms MPF governs the assembly and contraction of actomyosin rings by activating RhoA and MAPK during chemical-induced cytokinesis of goat oocytes Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20.Characterization of a novel kinetochore protein, CENP-H Mitotic regulation of the APC activator proteins CDC20 and CDH1 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint The anaphase promoting complex/cyclosome: a machine designed to destroy Localization of Mad2 to kinetochores depends on microtubule attachment, not tension Kinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells.Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase Kinetochore localization of spindle checkpoint proteins: who controls whom?

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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

http://www.wikidata.org/entity/Q24648493

description

1997 nî lūn-bûn

@nan

1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1997年の論文

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1997年論文

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1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

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1997年論文

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1997年论文

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name

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@ast

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@en

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@nl

type

label

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@ast

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@en

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@nl

prefLabel

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@ast

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@en

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@nl

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PNAS.94.23.12431

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Proceedings of the National Academy of Sciences of the United States of America

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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

@en

P2093

C Gorbea

http://www.w3.org/2001/XMLSchema#string

D Mahaffey

http://www.w3.org/2001/XMLSchema#string

M Rechsteiner

http://www.w3.org/2001/XMLSchema#string

R Benezra

http://www.w3.org/2001/XMLSchema#string

Y Li

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a human mitotic checkpoint gene: hsMAD2

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast

The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex

Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae.

Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

Feedback control of mitosis in budding yeast

Cyclin is degraded by the ubiquitin pathway

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

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94

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24983

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