Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif - Wikidata - awgldk - TriplyDB

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

http://www.wikidata.org/entity/Q24649769

about

Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1 Ubiquitination-mediated regulation of interferon responses Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor The cell biology of the unfolded protein response.West Nile virus infection induces depletion of IFNAR1 protein levels Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor.Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor.Ligand-independent interaction of the type I interferon receptor complex is necessary to observe its biological activity.Eliminative signaling by Janus kinases: role in the downregulation of associated receptors.The interferons and their receptors--distribution and regulation.Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy.SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells.Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses.The molecular basis for differential type I interferon signaling.RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding.Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.Downregulation of the IFNAR1 chain of type 1 interferon receptor contributes to the maintenance of the haematopoietic stem cells.The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.

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P2860

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

http://www.wikidata.org/entity/Q24649769

description

2008 nî lūn-bûn

@nan

2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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type

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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Basal ubiquitin-independent in ...... ng of a linear endocytic motif

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P1433

Journal of Biological Chemistry

P1476

Basal ubiquitin-independent in ...... ng of a linear endocytic motif

@en

P2093

Anamika Banerjee

http://www.w3.org/2001/XMLSchema#string

Bentley Varghese

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Darren P Baker

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K G Suresh Kumar

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Serge Y Fuchs

http://www.w3.org/2001/XMLSchema#string

Stefan N Constantinescu

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P2860

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor

Themes and variations on ubiquitylation

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity

Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction

Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

Signals for sorting of transmembrane proteins to endosomes and lysosomes

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18566-72

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scholarly article

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10.1074/JBC.M800991200

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P433

27

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283

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Sandra Pellegrini

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2008-07-04T00:00:00Z

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P698

18474601

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P932

2441555

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