The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesInsights into cytokine-receptor interactions from cytokine engineeringInterferon induction by RNA viruses and antagonism by viral pathogensStructural Linkage between Ligand Discrimination and Receptor Activation by Type I InterferonsStructural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyDisease-promoting effects of type I interferons in viral, bacterial, and coinfectionsDespite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokinesHigh efficiency cell-specific targeting of cytokine activityStructural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes.Interaction between innate immunity and porcine reproductive and respiratory syndrome virus.Evaluating annotations of an Agilent expression chip suggests that many features cannot be interpretedConformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response.Temporal and spatial resolution of type I and III interferon responses in vivo.Interferon-stimulated genes: a complex web of host defenses.Differential activity of type I interferon subtypes for dendritic cell differentiationSubtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.Multifaceted activities of type I interferon are revealed by a receptor antagonist.Stochastic receptor expression determines cell fate upon interferon treatment.Interferon Beta and Interferon Alpha 2a Differentially Protect Head and Neck Cancer Cells from Vesicular Stomatitis Virus-Induced Oncolysis.Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord.A fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus.Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling.Binding of interferon reduces the force of unfolding for interferon receptor 1.Understanding cytokine and growth factor receptor activation mechanisms.Anti-CD20-interferon-β fusion protein therapy of murine B-cell lymphomas.Intracellular interferons in fish: a unique means to combat viral infection.Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers.Bridging the species divide: transgenic mice humanized for type-I interferon response.Cytokine-receptor interactions as drug targets.The interferons and their receptors--distribution and regulation.Type I IFN-mediated regulation of IL-1 production in inflammatory disorders.Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy.Multifarious determinants of cytokine receptor signaling specificity.Interferons in the central nervous system: a few instruments play many tunes.Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain.IFNA2: The prototypic human alpha interferon.The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.
P2860
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P2860
The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The stability of the ternary i ...... rential biological activities.
@en
The stability of the ternary i ...... rential biological activities.
@nl
type
label
The stability of the ternary i ...... rential biological activities.
@en
The stability of the ternary i ...... rential biological activities.
@nl
prefLabel
The stability of the ternary i ...... rential biological activities.
@en
The stability of the ternary i ...... rential biological activities.
@nl
P2093
P2860
P356
P1476
The stability of the ternary i ...... rential biological activities.
@en
P2093
Diego A Jaitin
Eyal Kalie
Gideon Schreiber
Jacob Piehler
Yulia Podoplelova
P2860
P304
32925-32936
P356
10.1074/JBC.M806019200
P407
P577
2008-09-18T00:00:00Z