The binding sites for cocaine and dopamine in the dopamine transporter overlap - Wikidata - awgldk - TriplyDB

The binding sites for cocaine and dopamine in the dopamine transporter overlap

The binding sites for cocaine and dopamine in the dopamine transporter overlap

http://www.wikidata.org/entity/Q24650126

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Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions Mechanisms of dopamine transporter regulation in normal and disease states X-ray structure of dopamine transporter elucidates antidepressant mechanism R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties Insights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDAT Designing modulators of monoamine transporters using virtual screening techniques Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus Neurotransmitter and psychostimulant recognition by the dopamine transporter.Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologue Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter Classic Studies on the Interaction of Cocaine and the Dopamine Transporter Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.Modelling and mutational analysis of Aspergillus nidulans UreA, a member of the subfamily of urea/H⁺ transporters in fungi and plants Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling.Ligand effects on cross-linking support a conformational mechanism for serotonin transport.Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder Molecular modeling and ligand docking for solute carrier (SLC) transporters Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.Comparison of human solute carriers Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.SLC6 family transporter SNF-10 is required for protease-mediated activation of sperm motility in C. elegans Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression.

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

http://www.wikidata.org/entity/Q24650126

description

2008 nî lūn-bûn

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2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

The binding sites for cocaine and dopamine in the dopamine transporter overlap

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

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type

label

The binding sites for cocaine and dopamine in the dopamine transporter overlap

@ast

The binding sites for cocaine and dopamine in the dopamine transporter overlap

@en

The binding sites for cocaine and dopamine in the dopamine transporter overlap

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prefLabel

The binding sites for cocaine and dopamine in the dopamine transporter overlap

@ast

The binding sites for cocaine and dopamine in the dopamine transporter overlap

@en

The binding sites for cocaine and dopamine in the dopamine transporter overlap

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Nature Neuroscience

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

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Claus J Loland

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Harel Weinstein

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Jonathan A Javitch

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Julie Kniazeff

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Klaudia Raniszewska

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Lei Shi

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Luis Gracia

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Marianne L Bergmann

http://www.w3.org/2001/XMLSchema#string

Thijs Beuming

http://www.w3.org/2001/XMLSchema#string

Ulrik Gether

http://www.w3.org/2001/XMLSchema#string

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

Neurotransmitter transporters and their impact on the development of psychopharmacology

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6

The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands

Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition

Neurotransmitter transporters: molecular function of important drug targets

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

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780-9

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10.1038/NN.2146

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7

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Amy Hauck Newman

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