Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.

Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.

Item
http://www.wikidata.org/entity/Q33799683
Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextDuloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter.The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter.Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113.A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transportAntagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeMonoamine transporters: vulnerable and vital doorkeepers.Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.Comparative modeling of the human monoamine transporters: similarities in substrate binding.Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling.
P2860

Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.

Item
http://www.wikidata.org/entity/Q33799683
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@ast
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@en
type
label
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@ast
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@en
prefLabel
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@ast
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932
P356
P1433
P1476
Transmembrane domain 6 of the ...... ethylene dioxymethamphetamine.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932