Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel - Wikidata - awgldk - TriplyDB

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

http://www.wikidata.org/entity/Q24651543

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Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro Structural basis for the function and inhibition of an influenza virus proton channel Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding Mechanism of drug inhibition and drug resistance of influenza A M2 channel Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo An assay suitable for high throughput screening of anti-influenza drugs Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter The Influenza M2 Ectodomain Regulates the Conformational Equilibria of the Transmembrane Proton Channel: Insights from Solid-State Nuclear Magnetic Resonance Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface.Emerging antiviral targets for influenza A virus.Structures of influenza A proteins and insights into antiviral drug targets.Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins.Human monoclonal antibodies broadly neutralizing against influenza B virus.Pandemism of swine flu and its prospective drug therapy.Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening.Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.Structural basis for proton conduction and inhibition by the influenza M2 protein.Conformational analysis of the full-length M2 protein of the influenza A virus using solid-state NMR.Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.Conformational heterogeneity of the M2 proton channel and a structural model for channel activation Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel.Where does amantadine bind to the influenza virus M2 proton channel?Coexistence of two adamantane binding sites in the influenza A M2 ion channel.The effect of rosuvastatin in a murine model of influenza A infection.Proton association constants of His 37 in the Influenza-A M218-60 dimer-of-dimers.Emerging antiviral resistant strains of influenza A and the potential therapeutic targets within the viral ribonucleoprotein (vRNP) complex.Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus Functional reconstitution of influenza A M2(22-62).Viral miniproteins Effect of cytosolic pH on inward currents reveals structural characteristics of the proton transport cycle in the influenza A protein M2 in cell-free membrane patches of Xenopus oocytes Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages NMR determination of protein partitioning into membrane domains with different curvatures and application to the influenza M2 peptide.Investigation of the curvature induction and membrane localization of the influenza virus M2 protein using static and off-magic-angle spinning solid-state nuclear magnetic resonance of oriented bicelles.Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity

P2860

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P2860

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

http://www.wikidata.org/entity/Q24651543

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2008 nî lūn-bûn

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2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2008 թվականի օգոստոսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Functional studies indicate am ...... 2 proton-selective ion channel

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Functional studies indicate am ...... 2 proton-selective ion channel

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Functional studies indicate am ...... 2 proton-selective ion channel

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Functional studies indicate am ...... 2 proton-selective ion channel

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Functional studies indicate am ...... 2 proton-selective ion channel

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Proceedings of the National Academy of Sciences of the United States of America

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Functional studies indicate am ...... 2 proton-selective ion channel

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P2093

Chunlong Ma

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Fernando A Oliveira

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Lawrence H Pinto

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Robert A Lamb

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Theodore S Jardetzky

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Xianghong Jing

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Yuki Ohigashi

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P2860

New low-viscosity overlay medium for viral plaque assays

Structure and mechanism of the M2 proton channel of influenza A virus

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

Structural basis for the function and inhibition of an influenza virus proton channel

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

Generation of influenza A viruses entirely from cloned cDNAs

Analysis of the pore structure of the influenza A virus M(2) ion channel by the substituted-cysteine accessibility method

Transmembrane four-helix bundle of influenza A M2 protein channel: structural implications from helix tilt and orientation

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