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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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M2e-Based Universal Influenza A Vaccines Viral Membrane Channels: Role and Function in the Virus Life Cycle Computational Docking Study of p7 Ion Channel from HCV Genotype 3 and Genotype 4 and Its Interaction with Natural Compounds Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro Solution structure and functional analysis of the influenza B proton channel Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release Influenza M2 proton channels Designing inhibitors of M2 proton channel against H1N1 swine influenza virus Predicting drug-target interaction networks based on functional groups and biological features Analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks Study on phylogenetic relationships, variability, and correlated mutations in M2 proteins of influenza virus A Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo Novel inhibitor design for hemagglutinin against H1N1 influenza virus by core hopping method Two birds with one stone? Possible dual-targeting H1N1 inhibitors from traditional Chinese medicine Locking the 150-cavity open: in silico design and verification of influenza neuraminidase inhibitors iCTX-type: a sequence-based predictor for identifying the types of conotoxins in targeting ion channels iEzy-drug: a web server for identifying the interaction between enzymes and drugs in cellular networking NMR structures of polytopic integral membrane proteins.Avian influenza A H5N1 virus: a continuous threat to humans.Drug resistance in influenza A virus: the epidemiology and management.Extreme evolutionary conservation of functionally important regions in H1N1 influenza proteome.Newly Emergent Highly Pathogenic H5N9 Subtype Avian Influenza A Virus.Structures of influenza A proteins and insights into antiviral drug targets.Progress in structure-based drug design against influenza A virus.Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.pH-dependent conformation, dynamics, and aromatic interaction of the gating tryptophan residue of the influenza M2 proton channel from solid-state NMR Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR.Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N).Conformational heterogeneity of the M2 proton channel and a structural model for channel activation Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.Adamantane resistance in seasonal human influenza A viruses from Calgary, Alberta (January 2007 to August 2008).Where does amantadine bind to the influenza virus M2 proton channel?Coexistence of two adamantane binding sites in the influenza A M2 ion channel.Magic angle spinning NMR investigation of influenza A M2(18-60): support for an allosteric mechanism of inhibition

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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Proceedings of the National Academy of Sciences of the United States of America

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

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James J Chou

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Jason R Schnell

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Rafal M Pielak

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P2860

The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor

Structure and mechanism of the M2 proton channel of influenza A virus

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

Structural basis for the function and inhibition of an influenza virus proton channel

The Xplor-NIH NMR molecular structure determination package

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus

Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

Viral and cellular small integral membrane proteins can modify ion channels endogenous to Xenopus oocytes

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