The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway - Wikidata - awgldk - TriplyDB

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

http://www.wikidata.org/entity/Q24652634

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Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases Rad GTPase deficiency leads to cardiac hypertrophy Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity Regulation of RhoA-dependent ROCKII activation by Shp2 Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy RhoE binds to ROCK I and inhibits downstream signaling Expression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPase Regulation of ROCK activity in cancer Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα Structure of the GDP-bound G domain of the RGK protein Rem2 Active gene repression by the Egr2.NAB complex during peripheral nerve myelination N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo.GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection.Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes.The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.Rho kinase: an important mediator of atherosclerosis and vascular disease.Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.Ser1333 phosphorylation indicates ROCKI activation.Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.Crystal structure of human Rad GTPase of the RGK-family.Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage.Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes.ROCKs as therapeutic targets in cardiovascular diseases Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges.Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases

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P2860

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

http://www.wikidata.org/entity/Q24652634

description

2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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prefLabel

The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway

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Beth Spinelli

http://www.w3.org/2001/XMLSchema#string

Fumio Matsumura

http://www.w3.org/2001/XMLSchema#string

Kathleen Kelly

http://www.w3.org/2001/XMLSchema#string

Masaaki Ito

http://www.w3.org/2001/XMLSchema#string

Seow-Fong Yap

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V Ravichandran

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Yvona Ward

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P2860

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

Gem: an induced, immediate early protein belonging to the Ras family

Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans

Effects of phosphorylation on function of the Rad GTPase

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

Regulation and functions of Rho-associated kinase

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

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291-302

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scholarly article

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10.1083/JCB.200111026

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2

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157

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2002-04-15T00:00:00Z

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11411446

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11956230

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2199248

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