Discovery and characterization of a marine bacterial SAM-dependent chlorinase - Wikidata - awgldk - TriplyDB

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

http://www.wikidata.org/entity/Q24652817

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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution Insights into enzymatic halogenation from computational studies Mechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf-62)Halomethane Biosynthesis: Structure of a SAM-Dependent Halide Methyltransferase from Arabidopsis thaliana Mapping the Reaction Coordinates of Enzymatic Defluorination Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp.Structure-guided comparative analysis of proteins: principles, tools, and applications for predicting function.Linking species concepts to natural product discovery in the post-genomic era Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling.Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock.Insights from the sea: structural biology of marine polyketide synthases Natural and engineered biosynthesis of fluorinated natural products.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery Genomic basis for natural product biosynthetic diversity in the actinomycetes A sea of biosynthesis: marine natural products meet the molecular age.Diversity and biotechnological potential of microorganisms associated with marine sponges.Evolution of secondary metabolite genes in three closely related marine actinomycete species Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.Independent Evolution of Six Families of Halogenating Enzymes.Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase.S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.Chasing the treasures of the sea - bacterial marine natural products.Structural perspective on enzymatic halogenation.Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.Biosynthesis of polyketide synthase extender units.Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives.Challenges and triumphs to genomics-based natural product discovery Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.Introduction of fluorine and fluorine-containing functional groups.Functional diversity of organic molecule enzyme cofactors.Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria.Fluoro amino acids: a rarity in nature, yet a prospect for protein engineering.Multienzymatic synthesis of nucleic acid derivatives: a general perspective.Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway.

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

http://www.wikidata.org/entity/Q24652817

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2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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type

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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prefLabel

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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NCHEMBIO.2007.56

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Nature Chemical Biology

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Discovery and characterization of a marine bacterial SAM-dependent chlorinase

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Alessandra S Eustáquio

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Bradley S Moore

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Florence Pojer

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Joseph P Noel

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P2860

cDNA cloning of Batis maritima methyl chloride transferase and purification of the enzyme

Expression of Batis maritima methyl chloride transferase in Escherichia coli

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase

Crystal structure and mechanism of a bacterial fluorinating enzyme

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

The CCP4 suite: programs for protein crystallography

Structural quality assurance

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

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nchembio.2007.56

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