Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.
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Recent Advances in Understanding and Engineering Polyketide SynthesisRecent highlights in biosynthesis research using stable isotopesComplexity generation during natural product biosynthesis using redox enzymesVinylogous chain branching catalysed by a dedicated polyketide synthase moduleRational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin BiosynthesisTime-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciensThe enzymes of β-lactam biosynthesis.Propanol addition improves natamycin biosynthesis of Streptomyces natalensis.Engineering polyketide synthases and nonribosomal peptide synthetases.Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly lineRoles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Reinvigorating natural product combinatorial biosynthesis with synthetic biologyCharacterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivativeDesigned biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domainStructural analysis of protein-protein interactions in type I polyketide synthasesPolyketide stereocontrol: a study in chemical biology.Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.Synthetic biological approaches to natural product biosynthesis.The regulation and biosynthesis of antimycinsProgress challenges and opportunities for the re-engineering of trans-AT polyketide synthases.Recent advances in the biosynthesis of unusual polyketide synthase substrates.Methylobacterium extorquens: methylotrophy and biotechnological applications.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges.Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis.Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288.Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit.A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis.Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.De novo biosynthesis of terminal alkyne-labeled natural products.Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles.Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A.Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus.Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes.
P2860
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P2860
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@en
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@nl
type
label
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@en
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@nl
prefLabel
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@en
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@nl
P2860
P356
P1476
Beyond ethylmalonyl-CoA: the f ...... xpanding polyketide diversity.
@en
P2860
P356
10.1039/C1NP00082A
P577
2011-11-29T00:00:00Z