Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder - Wikidata - awgldk - TriplyDB

Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder

Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder

http://www.wikidata.org/entity/Q24654694

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Adrenal insufficiency in patients with decompensated cirrhosis Glucocorticoids and chronic inflammation Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressiv The human glucocorticoid receptor: molecular basis of biologic function Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess.A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.Familial glucocorticoid resistance caused by a novel frameshift glucocorticoid receptor mutation.Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor.Diagnosis of diseases of steroid hormone production, metabolism and action.Non polycystic ovary syndrome-related endocrine disorders associated with hirsutism.Stress response and child health.Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients Influence of glucocorticoid receptor gene NR3C1 646 C>G polymorphism on glucocorticoid resistance in asthmatics: a preliminary study.Single nucleotide polymorphisms of HSP90AA1 gene influence response of SLE patients to glucocorticoids treatment.Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains.A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD.Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis.The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis.Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level.Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders.Pharmacogenetics in reproductive and perinatal medicine.Effects of Chronic ACTH Excess on Human Adrenal Cortex.Psychological stress as a modulator of functional recovery following spinal cord injury.Anti-inflammatory glucocorticoid drugs: reflections after 60 years.Biologics, an alternative therapeutic approach for oral lichen planus.Glucocorticoid sensitivity in health and disease.Pharmacology of intra-articular triamcinolone.Chrousos syndrome: from molecular pathogenesis to therapeutic management.Bioengineered Colorectal Cancer Drugs: Orally Delivered Anti-Inflammatory Agents.PCOS remains a diagnosis of exclusion: a concise review of key endocrinopathies to exclude.A novel mutation of the hGR gene causing Chrousos syndrome.Primary generalized glucocorticoid resistance and hypersensitivity: the end-organ involvement in the stress response.Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals.Functional characterization of the hGRαT556I causing Chrousos syndrome.Glucocorticoid receptor auto-upregulation and its relation with glucocorticoid sensitivity in idiopathic nephrotic syndrome.An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature.

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P2860

Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder

http://www.wikidata.org/entity/Q24654694

description

2008 nî lūn-bûn

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2008 թվականի մայիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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name

Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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The Journal of Clinical Endocrinology and Metabolism

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Generalized glucocorticoid res ...... ons of a rare genetic disorder

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George P Chrousos

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Takamasa Ichijo

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Tomoshige Kino

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P2860

A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity

A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance

GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

Structure and specificity of nuclear receptor-coactivator interactions

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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1563-1572

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scholarly article

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3271918

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10.1210/JC.2008-0040

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5

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93

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Evangelia Charmandari

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5533561

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18319312

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2386273

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