Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues
about
Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseStructural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analoguesExtending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinaseRetrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activationPotent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine KinaseDeoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistanceThe apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cellsCell fate control gene therapy based on engineered variants of human deoxycytidine kinaseNovel application of lentiviral vectors towards treatment of graft-versus-host disease.Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy.New insights into the synergism of nucleoside analogs with radiotherapyBystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.Bacterial deoxyribonucleoside kinases are poor suicide genes in mammalian cells.
P2860
Q24625285-A55D4D40-03D4-4CE3-B610-04AF3A93AD04Q24629752-48559A2A-CDFE-401E-AECD-9EB39CB22D61Q24658022-0EC8BCB4-0480-4568-8525-3B3FFA907C99Q28482505-7FB949DC-291A-49F6-B3F6-70751CCFC41EQ28550404-DE9EC352-B9B7-4923-852F-15272B808519Q34015533-DA7607BD-DFB9-47CD-B7FC-EA97B966CA15Q34540846-7E8D13F7-3FDC-4BFA-92F9-7AAE48B0ED8BQ35939470-E29E401A-A75E-4349-8119-8D899D6E4283Q37489887-E2E29C24-3B0C-4A00-B285-BA92F7AE2700Q37989984-85DDDC21-DF13-44B3-8FA5-50E83B2ABE2DQ38143241-3C337CC5-92F5-434F-A3C9-7D01AEC6AD29Q39386066-569844B9-69FA-4BB4-B20E-3C77EBC6483CQ39640581-74584F9E-BE2B-462A-8B11-3933B7F891D8Q39660810-A0CBA8E5-F0A7-41E2-B946-65AF6B487FC5Q39735303-35373359-29BF-46B1-AF5C-1ED7577514E4
P2860
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@ast
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@en
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@nl
type
label
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@ast
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@en
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@nl
prefLabel
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@ast
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@en
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@nl
P2093
P2860
P921
P1433
P1476
Mimicking phosphorylation of S ...... tivity for dC and dC analogues
@en
P2093
Manfred Konrad
Saugata Hazra
Stephan Ort
Theresa McSorley
P2860
P356
10.1016/J.FEBSLET.2008.01.048
P407
P50
P577
2008-03-05T00:00:00Z