Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease
about
The importance of integrating basic and clinical research toward the development of new therapies for Huntington diseaseModulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseasesMouse models of polyglutamine diseases: review and data table. Part IFunctional Differences Between Direct and Indirect Striatal Output Pathways in Huntington's DiseaseGenetics and neuropathology of Huntington's diseaseA new drug design targeting the adenosinergic system for Huntington's diseaseThe Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviorsOnset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.Huntingtin is required for normal excitatory synapse development in cortical and striatal circuitsImprovement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.Studies on the Q175 Knock-in Model of Huntington's Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory DysfunctionNeurochemical correlates of caudate atrophy in Huntington's disease.Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and AmpakinesDifferential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.Selective roles of normal and mutant huntingtin in neural induction and early neurogenesisDifferential electrophysiological changes in striatal output neurons in Huntington's disease.Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington diseaseFunctional Changes in Neocortical Activity in Huntington's Disease Model Mice: An in vivo Intracellular Study.Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington diseaseForebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington's Disease Mice.Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction.Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior.Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease.Up-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease.Ca(2+) handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's diseaseA critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease.The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease miceAllosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's diseaseNicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3).Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's diseaseAcetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure.Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models.Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background.
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P2860
Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Age-dependent alterations of c ...... se model of Huntington disease
@ast
Age-dependent alterations of c ...... se model of Huntington disease
@en
Age-dependent alterations of c ...... se model of Huntington disease
@nl
type
label
Age-dependent alterations of c ...... se model of Huntington disease
@ast
Age-dependent alterations of c ...... se model of Huntington disease
@en
Age-dependent alterations of c ...... se model of Huntington disease
@nl
prefLabel
Age-dependent alterations of c ...... se model of Huntington disease
@ast
Age-dependent alterations of c ...... se model of Huntington disease
@en
Age-dependent alterations of c ...... se model of Huntington disease
@nl
P2093
P2860
P50
P3181
P1476
Age-dependent alterations of c ...... se model of Huntington disease
@en
P2093
Carlos Cepeda
Michael S Levine
Nan-Ping Wu
Nigel S Bamford
Prasad R Joshi
Véronique M André
P2860
P304
P3181
P356
10.1523/JNEUROSCI.5687-08.2009
P407
P577
2009-02-01T00:00:00Z