Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
about
MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin geneInsulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activityDevelopment of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiationAMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cellsThe PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoterMechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Gene expression in pancreatic adenocarcinoma.Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.MAFA controls genes implicated in insulin biosynthesis and secretionPancreatic Duodenal Homeobox (PDX-1) in health and disease.Glucotoxicity and beta-cell failure in type 2 diabetes mellitus.Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.Hyperinsulinism in infancy: from basic science to clinical disease.Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.Expression, purification, and characterization of recombinant human pancreatic duodenal homeobox-1 protein in Pichia pastoris.MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.Short-term regulation of insulin gene transcription by glucose.Novel autoantigens in type 1 diabetes.Insulin producing cells established using non-integrated lentiviral vector harboring PDX1 gene.Caudal dysgenesis in Islet-1 transgenic mice.Signal control through Raf: in sickness and in health.Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1.Pancreatic differentiation of human dental pulp CD117⁺ stem cells.The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression.ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcriptionInsulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter.The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation.Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor.
P2860
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P2860
Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Purification of the beta-cell ...... al and transformed islet cells
@ast
Purification of the beta-cell ...... al and transformed islet cells
@en
Purification of the beta-cell ...... al and transformed islet cells
@nl
type
label
Purification of the beta-cell ...... al and transformed islet cells
@ast
Purification of the beta-cell ...... al and transformed islet cells
@en
Purification of the beta-cell ...... al and transformed islet cells
@nl
prefLabel
Purification of the beta-cell ...... al and transformed islet cells
@ast
Purification of the beta-cell ...... al and transformed islet cells
@en
Purification of the beta-cell ...... al and transformed islet cells
@nl
P2093
P2860
P356
P1476
Purification of the beta-cell ...... al and transformed islet cells
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.26.15057
P407
P577
1996-12-24T00:00:00Z