Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
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Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcriptionConditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell developmentNovel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1.Epigenetics: a molecular link between environmental factors and type 2 diabetesFoxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expressionHistone deacetylases as targets for treatment of multiple diseasesPax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretionThe PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoterRegulation of the insulin gene by glucose and fatty acidsPancreatic beta cells require NeuroD to achieve and maintain functional maturityCovalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA bindingRole of phospholipase D1 in glucose-induced insulin secretion in pancreatic Beta cells.Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.NFAT targets signaling molecules to gene promoters in pancreatic β-cells.Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function.Endoplasmic reticulum stress and insulin biosynthesis: a reviewExpression, purification, and characterization of recombinant human pancreatic duodenal homeobox-1 protein in Pichia pastoris.MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cellsSSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.Exendin-4 enhances expression of Neurod1 and Glut2 in insulin-producing cells derived from mouse embryonic stem cells.Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.Expression and function of Set7/9 in pancreatic isletsEndoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.Stem cells to pancreatic beta-cells: new sources for diabetes cell therapyIslet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cellsHuman Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks.Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.
P2860
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P2860
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Insulin gene transcription is ...... ator and PDX-1, BETA2, and E47
@nl
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@ast
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@en
type
label
Insulin gene transcription is ...... ator and PDX-1, BETA2, and E47
@nl
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@ast
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@en
prefLabel
Insulin gene transcription is ...... ator and PDX-1, BETA2, and E47
@nl
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@ast
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@en
P2093
P2860
P1476
Insulin gene transcription is ...... tor and PDX-1, BETA2, and E47.
@en
P2093
P2860
P304
P356
10.1128/MCB.22.2.412-420.2002
P407
P577
2002-01-01T00:00:00Z